Journal: Biomicrofluidics
Article Title: Biophysical analysis of fluid shear stress induced cellular deformation in a microfluidic device
doi: 10.1063/1.5063824
Figure Lengend Snippet: The microfluidic device utilizes an array of traps to isolate and capture single CTCs and then challenges them with precise magnitudes of fluid shear stress. (a) A complete schematic of the entire microfluidic device. (b) Traps were offset to optimize the ability to capture and isolate single cells. (c) COMSOL Multiphysics simulations of the velocity profile of the device with the estimated path of cells depicted by the black stream line. (d) Calculation of FSS magnitudes dependent on the media flow rate into the device as calculated by the COMSOL point of the evaluation method.
Article Snippet: The microfluidic device was designed using the simulation software COMSOL Multiphysics v4.3 (COMSOL, Burlington, MA).
Techniques: Shear